Drug interactions
Calcium carbonate + Rilpivirine
Severity: Moderate
Calcium carbonate and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine needs an acidic stomach for absorption. Antacids raise gastric pH and can substantially reduce rilpivirine levels, risking loss of viral suppression.
What this interaction means in plain words
Calcium carbonate and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.
Why it happens
Increased gastric pH reduces rilpivirine solubility and oral absorption.
What to do
Give antacids at least 2 hours before or 4 hours after rilpivirine. For dolutegravir/rilpivirine, give antacids at least 6 hours after or 4 hours before.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Calcium carbonate with Rilpivirine?
MediHelp rates the interaction as moderate. Calcium carbonate and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine needs an acidic stomach for absorption. Antacids raise gastric pH and can substantially reduce rilpivirine levels, risking loss of viral suppression.
How serious is the interaction between Calcium carbonate and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give antacids at least 2 hours before or 4 hours after rilpivirine. For dolutegravir/rilpivirine, give antacids at least 6 hours after or 4 hours before.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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