Drug interactions
Calcium gluconate + Gemifloxacin
Severity: Moderate
Calcium gluconate and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium gluconate may bind gemifloxacin in the gut and lower its absorption, risking subtherapeutic antibiotic concentrations. Intravenous calcium gluconate does not share this absorption issue.
What this interaction means in plain words
Calcium gluconate and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium gluconate belongs to Gastrointestinal Tract; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Chelation of gemifloxacin by calcium cations in the gastrointestinal lumen.
What to do
Separate oral doses, giving gemifloxacin at least 2 hours before or 3 hours after calcium gluconate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium gluconate and Gemifloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Calcium gluconate
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium gluconate + Digoxin Major
- Alendronate + Calcium gluconate Moderate
- Amlodipine-atorvastatin + Calcium gluconate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate Moderate
Frequently asked questions
Can I take Calcium gluconate with Gemifloxacin?
MediHelp rates the interaction as moderate. Calcium gluconate and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium gluconate may bind gemifloxacin in the gut and lower its absorption, risking subtherapeutic antibiotic concentrations. Intravenous calcium gluconate does not share this absorption issue.
How serious is the interaction between Calcium gluconate and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral doses, giving gemifloxacin at least 2 hours before or 3 hours after calcium gluconate.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
