Drug interactions
Canagliflozin + Candesartan-hydrochlorothiazide
Severity: Moderate
Canagliflozin and Candesartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin causes osmotic diuresis and a small blood pressure reduction. Together with an ARB and a thiazide this may lead to volume depletion, hypotension and acute kidney injury.
What this interaction means in plain words
Canagliflozin and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Candesartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive natriuretic and volume-depleting effects.
What to do
Assess volume status before starting canagliflozin and consider lowering the diuretic dose. Monitor blood pressure and renal function after initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Canagliflozin and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin causes osmotic diuresis and a small blood pressure reduction. Together with an ARB and a thiazide this may lead to volume depletion, hypotension and acute kidney injury.
How serious is the interaction between Canagliflozin and Candesartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status before starting canagliflozin and consider lowering the diuretic dose. Monitor blood pressure and renal function after initiation.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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