Drug interactions
Canagliflozin + Enalapril-hydrochlorothiazide
Severity: Moderate
Canagliflozin and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin adds diuretic and blood pressure lowering effects, which can lead to volume depletion, hypotension and acute kidney injury with an ACE inhibitor and thiazide. It does not usually cause significant hyperkalemia, though some potassium rise is reported.
What this interaction means in plain words
Canagliflozin and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive natriuresis and volume depletion with ACE inhibitor hemodynamic effects on the kidney.
What to do
Assess volume status before starting and consider reducing the diuretic dose. Monitor blood pressure, renal function and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Canagliflozin and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin adds diuretic and blood pressure lowering effects, which can lead to volume depletion, hypotension and acute kidney injury with an ACE inhibitor and thiazide. It does not usually cause significant hyperkalemia, though some potassium rise is reported.
How serious is the interaction between Canagliflozin and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status before starting and consider reducing the diuretic dose. Monitor blood pressure, renal function and potassium.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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