Drug interactions
Canagliflozin + Fosinopril-hydrochlorothiazide
Severity: Moderate
Canagliflozin and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin causes osmotic diuresis and mild volume depletion, which together with an ACE inhibitor and thiazide may cause hypotension and acute kidney injury. Canagliflozin may also modestly alter potassium, and hyperkalemia has been reported with it in patients taking renin-angiotensin drugs.
What this interaction means in plain words
Canagliflozin and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive diuretic and volume-depleting effects with ACE inhibitor reduction of glomerular pressure.
What to do
Assess volume status and renal function before starting canagliflozin and consider reducing the diuretic dose. Monitor blood pressure, creatinine and potassium after initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Canagliflozin and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin causes osmotic diuresis and mild volume depletion, which together with an ACE inhibitor and thiazide may cause hypotension and acute kidney injury. Canagliflozin may also modestly alter potassium, and hyperkalemia has been reported with it in patients taking renin-angiotensin drugs.
How serious is the interaction between Canagliflozin and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before starting canagliflozin and consider reducing the diuretic dose. Monitor blood pressure, creatinine and potassium after initiation.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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