Drug interactions
Canagliflozin + Glyburide
Severity: Moderate
Canagliflozin and Glyburide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin lowers glucose independently of insulin, and combining it with a sulfonylurea such as glyburide raises the risk of hypoglycemia. Glyburide has a long duration of action, so low glucose can be prolonged and severe, especially in older adults or in patients with renal impairment.
What this interaction means in plain words
Canagliflozin and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Glyburide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering: SGLT2 inhibition promotes urinary glucose loss while glyburide stimulates insulin secretion.
What to do
Consider reducing the glyburide dose when canagliflozin is added. Monitor blood glucose and counsel the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Canagliflozin and Glyburide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Glyburide?
MediHelp rates the interaction as moderate. Canagliflozin and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin lowers glucose independently of insulin, and combining it with a sulfonylurea such as glyburide raises the risk of hypoglycemia. Glyburide has a long duration of action, so low glucose can be prolonged and severe, especially in older adults or in patients with renal impairment.
How serious is the interaction between Canagliflozin and Glyburide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when canagliflozin is added. Monitor blood glucose and counsel the patient on recognizing and treating hypoglycemia.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
