Drug interactions
Canagliflozin + Hydrochlorothiazide-losartan
Severity: Moderate
Canagliflozin and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin causes osmotic diuresis and mild natriuresis, which adds to the effect of hydrochlorothiazide and may cause volume depletion, hypotension and reduced renal function with losartan. Canagliflozin may raise potassium slightly in some patients.
What this interaction means in plain words
Canagliflozin and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive diuresis and volume depletion with RAAS blockade, affecting renal hemodynamics.
What to do
Assess volume status before starting canagliflozin and consider lowering the diuretic dose if needed. Monitor blood pressure, renal function and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Canagliflozin and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin causes osmotic diuresis and mild natriuresis, which adds to the effect of hydrochlorothiazide and may cause volume depletion, hypotension and reduced renal function with losartan. Canagliflozin may raise potassium slightly in some patients.
How serious is the interaction between Canagliflozin and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status before starting canagliflozin and consider lowering the diuretic dose if needed. Monitor blood pressure, renal function and potassium.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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