Drug interactions
Canagliflozin + Ritonavir
Severity: Moderate
Canagliflozin and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir may induce UGT enzymes and lower canagliflozin exposure, potentially reducing glycemic control. The effect is less established than with rifampin.
What this interaction means in plain words
Canagliflozin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir-related induction of UGT-mediated glucuronidation may increase canagliflozin clearance.
What to do
Monitor blood glucose when ritonavir is started or stopped. Consider adjusting canagliflozin dose or using an alternative agent if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Canagliflozin with Ritonavir?
MediHelp rates the interaction as moderate. Canagliflozin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir may induce UGT enzymes and lower canagliflozin exposure, potentially reducing glycemic control. The effect is less established than with rifampin.
How serious is the interaction between Canagliflozin and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ritonavir is started or stopped. Consider adjusting canagliflozin dose or using an alternative agent if control is inadequate.
What other medicines interact with Canagliflozin?
MediHelp also lists interactions of Canagliflozin with, for example, Aliskiren, Amiloride, Amlodipine-benazepril. The full list is on the Canagliflozin page.
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