Drug interactions
Canagliflozin + Tolazamide
Severity: Moderate
Canagliflozin and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin adds glucose-lowering effect to a sulfonylurea, increasing the risk of hypoglycemia. A sulfonylurea dose reduction is often needed when starting the SGLT2 inhibitor.
What this interaction means in plain words
Canagliflozin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive glucose lowering from sulfonylurea-stimulated insulin secretion and SGLT2-mediated glucosuria.
What to do
Consider reducing the tolazamide dose when starting canagliflozin and monitor blood glucose. Educate the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Tolazamide?
MediHelp rates the interaction as moderate. Canagliflozin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin adds glucose-lowering effect to a sulfonylurea, increasing the risk of hypoglycemia. A sulfonylurea dose reduction is often needed when starting the SGLT2 inhibitor.
How serious is the interaction between Canagliflozin and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tolazamide dose when starting canagliflozin and monitor blood glucose. Educate the patient on hypoglycemia symptoms.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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