Drug interactions
Canagliflozin + Voclosporin
Severity: Moderate
Canagliflozin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can cause hyperkalemia and reduce renal function. Canagliflozin may modestly raise potassium and alters renal hemodynamics, so combined use may compound these effects.
What this interaction means in plain words
Canagliflozin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Voclosporin belongs to Miscellaneous.
Why it happens
Additive effects on potassium: calcineurin inhibition impairs renal potassium excretion while canagliflozin may modestly raise potassium.
What to do
Monitor serum potassium and eGFR regularly during combined therapy. Adjust therapy if hyperkalemia or declining renal function develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Canagliflozin with Voclosporin?
MediHelp rates the interaction as moderate. Canagliflozin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, can cause hyperkalemia and reduce renal function. Canagliflozin may modestly raise potassium and alters renal hemodynamics, so combined use may compound these effects.
How serious is the interaction between Canagliflozin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and eGFR regularly during combined therapy. Adjust therapy if hyperkalemia or declining renal function develops.
What other medicines interact with Canagliflozin?
MediHelp also lists interactions of Canagliflozin with, for example, Aliskiren, Amiloride, Amlodipine-benazepril. The full list is on the Canagliflozin page.
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