Drug interactions
Canagliflozin-metformin + Chlorpromazine
Severity: Moderate
Canagliflozin-metformin and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine can impair glucose tolerance and cause hyperglycemia, reducing the effect of antidiabetic drugs. Glucose may fall again when the phenothiazine is stopped.
What this interaction means in plain words
Canagliflozin-metformin and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Chlorpromazine belongs to Central Nervous System.
Why it happens
Antipsychotic-related insulin resistance and reduced insulin secretion oppose antidiabetic action.
What to do
Monitor blood glucose when starting, changing or stopping chlorpromazine and adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Chlorpromazine?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine can impair glucose tolerance and cause hyperglycemia, reducing the effect of antidiabetic drugs. Glucose may fall again when the phenothiazine is stopped.
How serious is the interaction between Canagliflozin-metformin and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, changing or stopping chlorpromazine and adjust antidiabetic doses as needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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