Drug interactions
Canagliflozin-metformin + Prochlorperazine
Severity: Minor
Canagliflozin-metformin and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as prochlorperazine may raise blood glucose, particularly with prolonged use. Short-term use rarely has clinical impact.
What this interaction means in plain words
Canagliflozin-metformin and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Prochlorperazine belongs to Central Nervous System.
Why it happens
Antipsychotic-related reduction in insulin sensitivity and secretion opposes antidiabetic effects.
What to do
Monitor blood glucose if used chronically or at high doses and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Canagliflozin-metformin with Prochlorperazine?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines such as prochlorperazine may raise blood glucose, particularly with prolonged use. Short-term use rarely has clinical impact.
How serious is the interaction between Canagliflozin-metformin and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if used chronically or at high doses and adjust antidiabetic therapy as needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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