Drug interactions
Canagliflozin-metformin + Vilazodone
Severity: Minor
Canagliflozin-metformin and Vilazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonergic antidepressants may rarely alter glucose levels and occasionally cause hypoglycemia in patients on antidiabetic drugs. Any effect is small with metformin and canagliflozin, which carry low intrinsic hypoglycemia risk.
What this interaction means in plain words
Canagliflozin-metformin and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Vilazodone belongs to Central Nervous System.
Why it happens
Mechanism not firmly established; possible effects of serotonergic activity on insulin sensitivity.
What to do
No dose adjustment is needed. Check glucose if symptoms of hypoglycemia occur after starting vilazodone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Vilazodone?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Serotonergic antidepressants may rarely alter glucose levels and occasionally cause hypoglycemia in patients on antidiabetic drugs. Any effect is small with metformin and canagliflozin, which carry low intrinsic hypoglycemia risk.
How serious is the interaction between Canagliflozin-metformin and Vilazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Check glucose if symptoms of hypoglycemia occur after starting vilazodone.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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