Drug interactions
Canakinumab + Everolimus
Severity: Moderate
Canakinumab and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canakinumab blocks interleukin-1 beta and everolimus suppresses immune function via mTOR. Combined use may raise the risk of serious infections.
What this interaction means in plain words
Canakinumab and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canakinumab belongs to Miscellaneous; Everolimus belongs to Oncology.
Why it happens
Additive immunosuppression through IL-1 beta blockade and mTOR inhibition.
What to do
Screen for latent infection such as tuberculosis and monitor for signs of infection during treatment. Hold one agent if a serious infection occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Other interactions of Canakinumab
- Adalimumab + Canakinumab Major
- Anakinra + Canakinumab Major
- Baricitinib + Canakinumab Major
- Basiliximab + Canakinumab Major
- Canakinumab + Etanercept Major
- Canakinumab + Golimumab Major
Frequently asked questions
Can I take Canakinumab with Everolimus?
MediHelp rates the interaction as moderate. Canakinumab and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canakinumab blocks interleukin-1 beta and everolimus suppresses immune function via mTOR. Combined use may raise the risk of serious infections.
How serious is the interaction between Canakinumab and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for latent infection such as tuberculosis and monitor for signs of infection during treatment. Hold one agent if a serious infection occurs.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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