Drug interactions
Canakinumab + Temsirolimus
Severity: Moderate
Canakinumab and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents impair immune defenses, so combined use may raise the risk of serious infection. Canakinumab labeling also notes a heightened infection risk with other immunosuppressants.
What this interaction means in plain words
Canakinumab and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canakinumab belongs to Miscellaneous; Temsirolimus belongs to Oncology.
Why it happens
Additive immunosuppression through mTOR inhibition and interleukin-1 beta blockade.
What to do
Monitor patients for signs of infection and treat promptly. Screen for latent tuberculosis before canakinumab and avoid use in active infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Canakinumab
- Adalimumab + Canakinumab Major
- Anakinra + Canakinumab Major
- Baricitinib + Canakinumab Major
- Basiliximab + Canakinumab Major
- Canakinumab + Etanercept Major
- Canakinumab + Golimumab Major
Frequently asked questions
Can I take Canakinumab with Temsirolimus?
MediHelp rates the interaction as moderate. Canakinumab and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents impair immune defenses, so combined use may raise the risk of serious infection. Canakinumab labeling also notes a heightened infection risk with other immunosuppressants.
How serious is the interaction between Canakinumab and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients for signs of infection and treat promptly. Screen for latent tuberculosis before canakinumab and avoid use in active infection.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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