Drug interactions
Candesartan-hydrochlorothiazide + Digoxin
Severity: Moderate
Candesartan-hydrochlorothiazide and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The thiazide component can lower serum potassium and magnesium, which sensitizes the myocardium to digoxin and raises the risk of digoxin-related arrhythmias. Candesartan may raise potassium, so the net electrolyte effect varies between patients.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Thiazide-induced hypokalemia and hypomagnesemia enhance digoxin's pharmacodynamic effect on the myocardium, while the ARB can offset this by retaining potassium.
What to do
Monitor serum potassium, magnesium and renal function regularly and correct abnormalities. Check digoxin levels and watch for signs of toxicity or ECG changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Digoxin?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The thiazide component can lower serum potassium and magnesium, which sensitizes the myocardium to digoxin and raises the risk of digoxin-related arrhythmias. Candesartan may raise potassium, so the net electrolyte effect varies between patients.
How serious is the interaction between Candesartan-hydrochlorothiazide and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium and renal function regularly and correct abnormalities. Check digoxin levels and watch for signs of toxicity or ECG changes.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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