Drug interactions
Candesartan-hydrochlorothiazide + Entecavir
Severity: Minor
Candesartan-hydrochlorothiazide and Entecavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated renally by filtration and tubular secretion, so drugs that impair renal function can raise its exposure. Candesartan and hydrochlorothiazide can reduce renal function in volume-depleted patients, but a direct interaction is not well documented.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Entecavir belongs to Anti Virals.
Why it happens
Possible reduction in renal clearance of entecavir through changes in renal function or tubular secretion.
What to do
Monitor renal function and adjust entecavir dose to creatinine clearance if function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Entecavir
- Alogliptin-metformin + Entecavir Moderate
- Canagliflozin-metformin + Entecavir Moderate
- Cidofovir + Entecavir Moderate
- Cyclosporine + Entecavir Moderate
- Dapagliflozin-metformin + Entecavir Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Entecavir Moderate
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Entecavir?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Entecavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated renally by filtration and tubular secretion, so drugs that impair renal function can raise its exposure. Candesartan and hydrochlorothiazide can reduce renal function in volume-depleted patients, but a direct interaction is not well documented.
How serious is the interaction between Candesartan-hydrochlorothiazide and Entecavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and adjust entecavir dose to creatinine clearance if function declines.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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