Drug interactions
Candesartan-hydrochlorothiazide + Glipizide
Severity: Moderate
Candesartan-hydrochlorothiazide and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and may weaken the glucose-lowering effect of glipizide. The effect is usually modest at low thiazide doses but can matter in poorly controlled diabetes.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Glipizide belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion and sensitivity oppose sulfonylurea action.
What to do
Monitor blood glucose and HbA1c after starting the thiazide and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Candesartan-hydrochlorothiazide and Glipizide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Glipizide
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Glipizide?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and may weaken the glucose-lowering effect of glipizide. The effect is usually modest at low thiazide doses but can matter in poorly controlled diabetes.
How serious is the interaction between Candesartan-hydrochlorothiazide and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting the thiazide and adjust antidiabetic therapy if needed.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
