Drug interactions
Candesartan-hydrochlorothiazide + Vitamin d
Severity: Moderate
Candesartan-hydrochlorothiazide and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion, and with vitamin D supplements this can lead to hypercalcemia. The risk is higher with high vitamin D doses, calcium supplements or renal impairment.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Thiazides increase renal tubular calcium reabsorption while vitamin D increases intestinal calcium absorption.
What to do
Monitor serum calcium periodically, particularly with high-dose vitamin D or calcium. Reduce vitamin D or stop the thiazide if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Vitamin d
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Vitamin d?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, and with vitamin D supplements this can lead to hypercalcemia. The risk is higher with high vitamin D doses, calcium supplements or renal impairment.
How serious is the interaction between Candesartan-hydrochlorothiazide and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, particularly with high-dose vitamin D or calcium. Reduce vitamin D or stop the thiazide if hypercalcemia occurs.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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