Drug interactions
Cannabidiol + Enzalutamide
Severity: Moderate
Cannabidiol and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide induces CYP3A4 and CYP2C19, both of which contribute to cannabidiol clearance, so cannabidiol exposure may fall and seizure control may worsen. Cannabidiol may also inhibit some enzymes, but the net effect is expected to be reduced cannabidiol activity.
What this interaction means in plain words
Cannabidiol and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4 and CYP2C19, increasing the metabolism of cannabidiol.
What to do
Monitor seizure control and tolerability, and increase the cannabidiol dose according to response if needed. Reassess the dose if enzalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Enzalutamide?
MediHelp rates the interaction as moderate. Cannabidiol and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide induces CYP3A4 and CYP2C19, both of which contribute to cannabidiol clearance, so cannabidiol exposure may fall and seizure control may worsen. Cannabidiol may also inhibit some enzymes, but the net effect is expected to be reduced cannabidiol activity.
How serious is the interaction between Cannabidiol and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and tolerability, and increase the cannabidiol dose according to response if needed. Reassess the dose if enzalutamide is stopped.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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