Drug interactions
Cannabidiol + Posaconazole
Severity: Moderate
Cannabidiol and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol is partly metabolized by CYP3A4, so posaconazole may increase its concentrations. This may increase somnolence, sedation, and liver enzyme elevations.
What this interaction means in plain words
Cannabidiol and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 reduces cannabidiol clearance.
What to do
Consider reducing the cannabidiol dose and monitor for sedation, diarrhea and liver enzyme changes. Titrate to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Posaconazole?
MediHelp rates the interaction as moderate. Cannabidiol and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol is partly metabolized by CYP3A4, so posaconazole may increase its concentrations. This may increase somnolence, sedation, and liver enzyme elevations.
How serious is the interaction between Cannabidiol and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the cannabidiol dose and monitor for sedation, diarrhea and liver enzyme changes. Titrate to clinical response.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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