Drug interactions
Cannabidiol + Progesterone
Severity: Minor
Cannabidiol and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19 and CYP3A4 and may increase progesterone exposure. This could increase dose-related effects such as sedation and dizziness, particularly with oral progesterone.
What this interaction means in plain words
Cannabidiol and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Progesterone belongs to Endocrine.
Why it happens
Cannabidiol inhibits CYP2C19 and CYP3A4, reducing progesterone metabolism.
What to do
Monitor for sedation and other progestogenic adverse effects and reduce the progesterone dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Progesterone?
MediHelp rates the interaction as minor. Cannabidiol and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol inhibits CYP2C19 and CYP3A4 and may increase progesterone exposure. This could increase dose-related effects such as sedation and dizziness, particularly with oral progesterone.
How serious is the interaction between Cannabidiol and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and other progestogenic adverse effects and reduce the progesterone dose if they occur.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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