Drug interactions
Cannabidiol + Propofol
Severity: Moderate
Cannabidiol and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol has sedative properties and may add to the CNS depressant effect of propofol. Cannabidiol also inhibits some CYP enzymes, but propofol is cleared by several pathways, so the pharmacokinetic effect is likely small.
What this interaction means in plain words
Cannabidiol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible minor CYP2C19 or CYP2C9 inhibition by cannabidiol.
What to do
Titrate propofol to effect and expect possibly lower dose requirements in patients taking cannabidiol. Monitor sedation depth and respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Propofol?
MediHelp rates the interaction as moderate. Cannabidiol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol has sedative properties and may add to the CNS depressant effect of propofol. Cannabidiol also inhibits some CYP enzymes, but propofol is cleared by several pathways, so the pharmacokinetic effect is likely small.
How serious is the interaction between Cannabidiol and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect and expect possibly lower dose requirements in patients taking cannabidiol. Monitor sedation depth and respiratory status.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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