Drug interactions
Cannabidiol + Ticlopidine
Severity: Moderate
Cannabidiol and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2C19, one of the enzymes metabolizing cannabidiol. Cannabidiol exposure may increase, with more sedation, somnolence or liver enzyme elevation.
What this interaction means in plain words
Cannabidiol and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Ticlopidine belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C19-mediated metabolism of cannabidiol and its active metabolite.
What to do
Consider reducing the cannabidiol dose and monitor for adverse effects and liver enzymes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Ticlopidine?
MediHelp rates the interaction as moderate. Cannabidiol and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits CYP2C19, one of the enzymes metabolizing cannabidiol. Cannabidiol exposure may increase, with more sedation, somnolence or liver enzyme elevation.
How serious is the interaction between Cannabidiol and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the cannabidiol dose and monitor for adverse effects and liver enzymes.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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