Drug interactions
Capecitabine + Disopyramide
Severity: Moderate
Capecitabine and Disopyramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide can prolong the QT interval and cause torsades de pointes. Capecitabine has rare reports of cardiac toxicity, so the combination may add some arrhythmia risk.
What this interaction means in plain words
Capecitabine and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Disopyramide belongs to Cardiovascular.
Why it happens
Disopyramide blocks cardiac sodium and potassium channels; capecitabine contribution to QT effect is minor and uncertain.
What to do
Obtain a baseline ECG, monitor QTc and correct potassium and magnesium abnormalities. Consider an alternative antiarrhythmic if QTc lengthens substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Capecitabine
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Capecitabine with Disopyramide?
MediHelp rates the interaction as moderate. Capecitabine and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide can prolong the QT interval and cause torsades de pointes. Capecitabine has rare reports of cardiac toxicity, so the combination may add some arrhythmia risk.
How serious is the interaction between Capecitabine and Disopyramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, monitor QTc and correct potassium and magnesium abnormalities. Consider an alternative antiarrhythmic if QTc lengthens substantially.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
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