Drug interactions
Capivasertib + Modafinil
Severity: Moderate
Capivasertib and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil is a weak to moderate CYP3A4 inducer and capivasertib is metabolised by CYP3A4. Reduced capivasertib exposure may lessen anticancer efficacy.
What this interaction means in plain words
Capivasertib and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Modafinil belongs to Central Nervous System.
Why it happens
Modafinil induces CYP3A4, increasing the metabolism of capivasertib.
What to do
Consider an alternative wakefulness agent that does not induce CYP3A4. If it must be used, monitor tumor response and consider the labeling advice for CYP3A inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Modafinil?
MediHelp rates the interaction as moderate. Capivasertib and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil is a weak to moderate CYP3A4 inducer and capivasertib is metabolised by CYP3A4. Reduced capivasertib exposure may lessen anticancer efficacy.
How serious is the interaction between Capivasertib and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative wakefulness agent that does not induce CYP3A4. If it must be used, monitor tumor response and consider the labeling advice for CYP3A inducers.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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