Drug interactions
Capmatinib + Itraconazole
Severity: Moderate
Capmatinib and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase capmatinib concentrations because capmatinib is a CYP3A4 substrate. Higher exposure could increase adverse effects such as hepatotoxicity, pneumonitis and edema.
What this interaction means in plain words
Capmatinib and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capmatinib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces metabolic clearance of capmatinib.
What to do
Monitor liver enzymes and for respiratory symptoms and edema. Consider an alternative antifungal or capmatinib dose interruption if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Capmatinib
- Amobarbital + Capmatinib Major
- Apalutamide + Capmatinib Major
- Capmatinib + Carbamazepine Major
- Capmatinib + Efavirenz Major
- Capmatinib + Enzalutamide Major
- Capmatinib + Phenytoin Major
Frequently asked questions
Can I take Capmatinib with Itraconazole?
MediHelp rates the interaction as moderate. Capmatinib and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase capmatinib concentrations because capmatinib is a CYP3A4 substrate. Higher exposure could increase adverse effects such as hepatotoxicity, pneumonitis and edema.
How serious is the interaction between Capmatinib and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and for respiratory symptoms and edema. Consider an alternative antifungal or capmatinib dose interruption if toxicity occurs.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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