Drug interactions
Capmatinib + Voriconazole
Severity: Moderate
Capmatinib and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase capmatinib exposure, possibly leading to more adverse effects such as hepatotoxicity, edema and nausea.
What this interaction means in plain words
Capmatinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capmatinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, a main route of capmatinib metabolism.
What to do
Monitor liver enzymes and other adverse effects, and consider an alternative antifungal if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Capmatinib
- Amobarbital + Capmatinib Major
- Apalutamide + Capmatinib Major
- Capmatinib + Carbamazepine Major
- Capmatinib + Efavirenz Major
- Capmatinib + Enzalutamide Major
- Capmatinib + Phenytoin Major
Frequently asked questions
Can I take Capmatinib with Voriconazole?
MediHelp rates the interaction as moderate. Capmatinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may increase capmatinib exposure, possibly leading to more adverse effects such as hepatotoxicity, edema and nausea.
How serious is the interaction between Capmatinib and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and other adverse effects, and consider an alternative antifungal if toxicity occurs.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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