Drug interactions
Chlorpropamide + Ertugliflozin-sitagliptin
Severity: Moderate
Chlorpropamide and Ertugliflozin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SGLT2 inhibitor and a DPP-4 inhibitor with a sulfonylurea increases the risk of hypoglycemia. The long half-life of chlorpropamide makes prolonged hypoglycemia a concern.
What this interaction means in plain words
Chlorpropamide and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Ertugliflozin-sitagliptin belongs to Endocrine.
Why it happens
Additive glucose-lowering effects, with insulin secretion stimulated by the sulfonylurea and sitagliptin.
What to do
Consider reducing the sulfonylurea dose when starting ertugliflozin-sitagliptin and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpropamide and Ertugliflozin-sitagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ertugliflozin-sitagliptin
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as moderate. Chlorpropamide and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SGLT2 inhibitor and a DPP-4 inhibitor with a sulfonylurea increases the risk of hypoglycemia. The long half-life of chlorpropamide makes prolonged hypoglycemia a concern.
How serious is the interaction between Chlorpropamide and Ertugliflozin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the sulfonylurea dose when starting ertugliflozin-sitagliptin and monitor blood glucose.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
