Drug interactions
Captopril + Rolapitant
Severity: Minor
Captopril and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Captopril is only partly metabolized by CYP2D6 and is mostly eliminated renally and as disulfide conjugates. A clinically significant interaction with rolapitant is unlikely.
What this interaction means in plain words
Captopril and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril belongs to Cardiovascular; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant's CYP2D6 inhibition could slightly affect a minor captopril metabolic pathway.
What to do
No dose adjustment is needed; monitor blood pressure as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Rolapitant?
MediHelp rates the interaction as minor. Captopril and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Captopril is only partly metabolized by CYP2D6 and is mostly eliminated renally and as disulfide conjugates. A clinically significant interaction with rolapitant is unlikely.
How serious is the interaction between Captopril and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor blood pressure as usual.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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