Drug interactions
Captopril + Silodosin
Severity: Minor
Captopril and Silodosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Captopril and silodosin both lower blood pressure, so first-dose or dose-change hypotension may be more pronounced. Most patients tolerate the combination.
What this interaction means in plain words
Captopril and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive hypotensive effects from alpha-1 adrenergic blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting either drug. Advise slow position changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Silodosin?
MediHelp rates the interaction as minor. Captopril and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Captopril and silodosin both lower blood pressure, so first-dose or dose-change hypotension may be more pronounced. Most patients tolerate the combination.
How serious is the interaction between Captopril and Silodosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting either drug. Advise slow position changes.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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