Drug interactions
Captopril-hydrochlorothiazide + Digoxin
Severity: Moderate
Captopril-hydrochlorothiazide and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-induced hypokalemia and hypomagnesemia increase sensitivity to digoxin and the risk of arrhythmias. Captopril may modestly raise digoxin levels, and renal impairment from ACE inhibition can further reduce digoxin clearance.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Diuretic-induced hypokalemia sensitizes the myocardium to digoxin, with possible reduced renal digoxin clearance from ACE inhibitor.
What to do
Monitor serum potassium, magnesium, renal function and digoxin levels, and keep potassium in the normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Digoxin?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-induced hypokalemia and hypomagnesemia increase sensitivity to digoxin and the risk of arrhythmias. Captopril may modestly raise digoxin levels, and renal impairment from ACE inhibition can further reduce digoxin clearance.
How serious is the interaction between Captopril-hydrochlorothiazide and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium, renal function and digoxin levels, and keep potassium in the normal range.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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