Drug interactions
Captopril-hydrochlorothiazide + Everolimus
Severity: Moderate
Captopril-hydrochlorothiazide and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus combined with an ACE inhibitor such as captopril raises the risk of angioedema. Reactions may affect the face, lips, tongue or airway and can be serious.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Everolimus belongs to Oncology.
Why it happens
Both drugs impair bradykinin breakdown (ACE inhibition plus mTOR inhibition effects on kinin metabolism), increasing bradykinin-mediated angioedema.
What to do
Counsel patients to report swelling of the face, lips, tongue or throat immediately. Stop the ACE inhibitor and treat if angioedema develops, and consider a different antihypertensive class.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Everolimus?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus combined with an ACE inhibitor such as captopril raises the risk of angioedema. Reactions may affect the face, lips, tongue or airway and can be serious.
How serious is the interaction between Captopril-hydrochlorothiazide and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling of the face, lips, tongue or throat immediately. Stop the ACE inhibitor and treat if angioedema develops, and consider a different antihypertensive class.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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