Drug interactions
Captopril-hydrochlorothiazide + Finerenone
Severity: Major
Captopril-hydrochlorothiazide and Finerenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Finerenone is a mineralocorticoid receptor antagonist and captopril reduces aldosterone, so both raise potassium. This increases the risk of hyperkalemia, especially in chronic kidney disease. Hydrochlorothiazide partially offsets this through potassium loss.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Finerenone belongs to Cardiovascular.
Why it happens
Additive potassium retention from mineralocorticoid receptor blockade and ACE inhibition.
What to do
Check serum potassium before starting and during therapy, and adjust or hold finerenone per labeled potassium thresholds. Monitor renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Finerenone?
MediHelp rates the interaction as major. Captopril-hydrochlorothiazide and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Finerenone is a mineralocorticoid receptor antagonist and captopril reduces aldosterone, so both raise potassium. This increases the risk of hyperkalemia, especially in chronic kidney disease. Hydrochlorothiazide partially offsets this through potassium loss.
How serious is the interaction between Captopril-hydrochlorothiazide and Finerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium before starting and during therapy, and adjust or hold finerenone per labeled potassium thresholds. Monitor renal function.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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