Drug interactions
Captopril-hydrochlorothiazide + Hydrochlorothiazide
Severity: Moderate
Captopril-hydrochlorothiazide and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains hydrochlorothiazide, so adding it separately duplicates the thiazide. This increases the risk of hypotension, volume depletion, electrolyte disturbance and renal impairment.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Therapeutic duplication of thiazide diuresis combined with ACE inhibition gives additive hypotensive and renal effects.
What to do
Avoid giving separate hydrochlorothiazide with the fixed-dose product unless the dose is deliberately adjusted. Monitor blood pressure, electrolytes and renal function if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination product already contains hydrochlorothiazide, so adding it separately duplicates the thiazide. This increases the risk of hypotension, volume depletion, electrolyte disturbance and renal impairment.
How serious is the interaction between Captopril-hydrochlorothiazide and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving separate hydrochlorothiazide with the fixed-dose product unless the dose is deliberately adjusted. Monitor blood pressure, electrolytes and renal function if both are used.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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