Drug interactions
Captopril-hydrochlorothiazide + Linagliptin
Severity: Moderate
Captopril-hydrochlorothiazide and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DPP-4 inhibitors given with ACE inhibitors have been associated with an increased risk of angioedema. The reaction can involve the face, tongue or airway and may be serious.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Linagliptin belongs to Endocrine.
Why it happens
Both ACE and DPP-4 degrade bradykinin and substance P, so inhibiting both pathways may increase kinin-mediated angioedema.
What to do
Counsel patients to seek urgent care for swelling of the lips, tongue or throat. Discontinue the offending drug and treat if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Linagliptin?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors given with ACE inhibitors have been associated with an increased risk of angioedema. The reaction can involve the face, tongue or airway and may be serious.
How serious is the interaction between Captopril-hydrochlorothiazide and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to seek urgent care for swelling of the lips, tongue or throat. Discontinue the offending drug and treat if angioedema occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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