Drug interactions
Captopril-hydrochlorothiazide + Methamphetamine
Severity: Moderate
Captopril-hydrochlorothiazide and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine raises blood pressure and heart rate and can counteract the effect of antihypertensive therapy. Control of hypertension may be lost while it is being used.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Methamphetamine belongs to Central Nervous System.
Why it happens
Sympathomimetic release of catecholamines causes vasoconstriction, opposing the effects of ACE inhibition and diuretic therapy.
What to do
Monitor blood pressure regularly and adjust antihypertensive therapy if control is lost. Reassess the need for the stimulant in patients with uncontrolled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Methamphetamine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine raises blood pressure and heart rate and can counteract the effect of antihypertensive therapy. Control of hypertension may be lost while it is being used.
How serious is the interaction between Captopril-hydrochlorothiazide and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure regularly and adjust antihypertensive therapy if control is lost. Reassess the need for the stimulant in patients with uncontrolled hypertension.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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