Drug interactions
Captopril-hydrochlorothiazide + Pentoxifylline
Severity: Minor
Captopril-hydrochlorothiazide and Pentoxifylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentoxifylline has vasodilating properties and can modestly lower blood pressure, so it may enhance the effect of antihypertensives. Symptomatic hypotension is uncommon but possible.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Pentoxifylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Pentoxifylline belongs to Cardiovascular.
Why it happens
Additive vasodilatory pharmacodynamic effect.
What to do
Monitor blood pressure when starting pentoxifylline and reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril-hydrochlorothiazide and Pentoxifylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Pentoxifylline
- Amifostine + Pentoxifylline Moderate
- Fluoxetine + Pentoxifylline Moderate
- Fluvoxamine + Pentoxifylline Moderate
- Insulin degludec / insulin aspart + Pentoxifylline Moderate
- Methoxsalen + Pentoxifylline Moderate
- Mexiletine + Pentoxifylline Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Pentoxifylline?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Pentoxifylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pentoxifylline has vasodilating properties and can modestly lower blood pressure, so it may enhance the effect of antihypertensives. Symptomatic hypotension is uncommon but possible.
How serious is the interaction between Captopril-hydrochlorothiazide and Pentoxifylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting pentoxifylline and reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
