Drug interactions
Captopril-hydrochlorothiazide + Pregabalin
Severity: Moderate
Captopril-hydrochlorothiazide and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angioedema has been reported with pregabalin, and ACE inhibitors are a well-known cause of angioedema. Patients taking both may have a higher risk of swelling of the face, lips, tongue and throat, which can compromise the airway.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Pregabalin belongs to Central Nervous System.
Why it happens
Additive risk of angioedema; ACE inhibitors raise bradykinin levels, while the mechanism for pregabalin is not well established.
What to do
Counsel patients to stop both drugs and seek urgent care if facial or throat swelling occurs. Avoid rechallenge with the ACE inhibitor after angioedema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Pregabalin?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angioedema has been reported with pregabalin, and ACE inhibitors are a well-known cause of angioedema. Patients taking both may have a higher risk of swelling of the face, lips, tongue and throat, which can compromise the airway.
How serious is the interaction between Captopril-hydrochlorothiazide and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to stop both drugs and seek urgent care if facial or throat swelling occurs. Avoid rechallenge with the ACE inhibitor after angioedema.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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