Drug interactions
Carbachol + Trimipramine
Severity: Minor
Carbachol and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a cholinergic agonist and trimipramine has antimuscarinic activity, so their effects oppose each other. Carbachol's therapeutic effect, for example in glaucoma, may be reduced, although systemic exposure from ophthalmic use is limited.
What this interaction means in plain words
Carbachol and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbachol belongs to Miscellaneous; Trimipramine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between cholinergic agonism and muscarinic blockade.
What to do
Monitor for reduced therapeutic response to carbachol, such as intraocular pressure when used for glaucoma.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Carbachol with Trimipramine?
MediHelp rates the interaction as minor. Carbachol and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbachol is a cholinergic agonist and trimipramine has antimuscarinic activity, so their effects oppose each other. Carbachol's therapeutic effect, for example in glaucoma, may be reduced, although systemic exposure from ophthalmic use is limited.
How serious is the interaction between Carbachol and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced therapeutic response to carbachol, such as intraocular pressure when used for glaucoma.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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