Drug interactions
Carbamazepine + Cinacalcet
Severity: Moderate
Carbamazepine and Cinacalcet: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may lower cinacalcet concentrations and lessen its calcium-lowering effect. Parathyroid hormone and calcium may then rise out of target range.
What this interaction means in plain words
Carbamazepine and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Cinacalcet belongs to Miscellaneous.
Why it happens
Carbamazepine induces CYP3A4, which contributes to cinacalcet metabolism.
What to do
Monitor serum calcium and parathyroid hormone after starting or stopping carbamazepine. Increase the cinacalcet dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Carbamazepine with Cinacalcet?
MediHelp rates the interaction as moderate. Carbamazepine and Cinacalcet can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may lower cinacalcet concentrations and lessen its calcium-lowering effect. Parathyroid hormone and calcium may then rise out of target range.
How serious is the interaction between Carbamazepine and Cinacalcet?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and parathyroid hormone after starting or stopping carbamazepine. Increase the cinacalcet dose if needed.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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