Drug interactions
carbamazepine + clarithromycin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ carbamazepine levels → ataxia, nystagmus, hyponatremia.
Mechanism of action
CYP3A4 inhibition.
Clinical management
Avoid or reduce CBZ with level monitoring; consider azithromycin instead.
Drug reference
References
- Carbamazepine interactions — SPS
- CBZ + macrolides — PubMed
Frequently asked questions
Can I take carbamazepine with clarithromycin?
The interaction is rated: Major. ↑ carbamazepine levels → ataxia, nystagmus, hyponatremia.
How serious is the interaction between carbamazepine and clarithromycin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between carbamazepine and clarithromycin managed?
Avoid or reduce CBZ with level monitoring; consider azithromycin instead.
Why do carbamazepine and clarithromycin interact?
CYP3A4 inhibition.
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