Drug interactions
Carbamazepine + Clobazam
Severity: Moderate
Carbamazepine and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so sedation, dizziness and ataxia may increase. Carbamazepine also induces CYP3A4 and lowers clobazam levels while increasing the active metabolite N-desmethylclobazam.
What this interaction means in plain words
Carbamazepine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Clobazam belongs to Central Nervous System.
Why it happens
Additive CNS depression plus carbamazepine induction of CYP3A4 altering clobazam and N-desmethylclobazam exposure.
What to do
Monitor for sedation and changes in seizure control and adjust clobazam dosing as needed. Check carbamazepine levels if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Carbamazepine with Clobazam?
MediHelp rates the interaction as moderate. Carbamazepine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so sedation, dizziness and ataxia may increase. Carbamazepine also induces CYP3A4 and lowers clobazam levels while increasing the active metabolite N-desmethylclobazam.
How serious is the interaction between Carbamazepine and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and changes in seizure control and adjust clobazam dosing as needed. Check carbamazepine levels if toxicity is suspected.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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