Drug interactions
Carbamazepine + Clorazepate
Severity: Moderate
Carbamazepine and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP3A4 and can lower levels of nordiazepam, the active metabolite of clorazepate, reducing its effectiveness. In patients treated for seizures or anxiety, this may reduce control, and withdrawal of carbamazepine may later raise benzodiazepine levels.
What this interaction means in plain words
Carbamazepine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Clorazepate belongs to Central Nervous System.
Why it happens
Induction of CYP3A4-mediated metabolism by carbamazepine increases clearance of the active metabolite.
What to do
Monitor clinical response and increase the clorazepate dose if needed. Reassess dosing and watch for sedation if carbamazepine is stopped or reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Clorazepate?
MediHelp rates the interaction as moderate. Carbamazepine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP3A4 and can lower levels of nordiazepam, the active metabolite of clorazepate, reducing its effectiveness. In patients treated for seizures or anxiety, this may reduce control, and withdrawal of carbamazepine may later raise benzodiazepine levels.
How serious is the interaction between Carbamazepine and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the clorazepate dose if needed. Reassess dosing and watch for sedation if carbamazepine is stopped or reduced.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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