Drug interactions
Carbamazepine + Dasatinib
Severity: Major
Carbamazepine and Dasatinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may sharply reduce dasatinib exposure and compromise treatment of leukemia. Similar strong inducers have markedly lowered dasatinib levels.
What this interaction means in plain words
Carbamazepine and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Dasatinib belongs to Oncology.
Why it happens
Carbamazepine induces CYP3A4, which increases the metabolism of dasatinib.
What to do
Use a non-inducing antiseizure drug. If unavoidable, monitor hematologic and molecular response and consider increasing the dasatinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Carbamazepine with Dasatinib?
MediHelp rates the interaction as major. Carbamazepine and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine may sharply reduce dasatinib exposure and compromise treatment of leukemia. Similar strong inducers have markedly lowered dasatinib levels.
How serious is the interaction between Carbamazepine and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing antiseizure drug. If unavoidable, monitor hematologic and molecular response and consider increasing the dasatinib dose.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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