Drug interactions
Carbamazepine + Ensitrelvir
Severity: Contraindicated
Carbamazepine and Ensitrelvir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is expected to reduce ensitrelvir concentrations substantially, which may lead to loss of antiviral activity and resistance. Strong CYP3A inducers are contraindicated with ensitrelvir.
What this interaction means in plain words
Carbamazepine and Ensitrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbamazepine belongs to Central Nervous System; Ensitrelvir belongs to Anti Virals.
Why it happens
Carbamazepine induces CYP3A4, accelerating ensitrelvir metabolism.
What to do
Avoid the combination and choose an alternative COVID-19 therapy or a non-inducing antiseizure drug. Do not stop carbamazepine abruptly without specialist advice.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ensitrelvir
- Apalutamide + Ensitrelvir Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Ensitrelvir + Ivabradine Contraindicated
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Ensitrelvir?
MediHelp rates the interaction as contraindicated. Carbamazepine and Ensitrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine is expected to reduce ensitrelvir concentrations substantially, which may lead to loss of antiviral activity and resistance. Strong CYP3A inducers are contraindicated with ensitrelvir.
How serious is the interaction between Carbamazepine and Ensitrelvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative COVID-19 therapy or a non-inducing antiseizure drug. Do not stop carbamazepine abruptly without specialist advice.
What other medicines interact with Ensitrelvir?
MediHelp also lists interactions of Ensitrelvir with, for example, Apalutamide, Colchicine, Enzalutamide. The full list is on the Ensitrelvir page.
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