Drug interactions
Carbamazepine + Edoxaban
Severity: Major
Carbamazepine and Edoxaban: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces P-glycoprotein and CYP enzymes and can reduce edoxaban exposure, risking thromboembolic events. Labeling advises avoiding potent P-gp inducers.
What this interaction means in plain words
Carbamazepine and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Edoxaban belongs to Cardiovascular.
Why it happens
Induction of P-glycoprotein (and some metabolism) reduces edoxaban absorption and increases clearance.
What to do
Avoid the combination and choose another anticoagulant or antiepileptic. If unavoidable, monitor for thrombosis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Edoxaban?
MediHelp rates the interaction as major. Carbamazepine and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine induces P-glycoprotein and CYP enzymes and can reduce edoxaban exposure, risking thromboembolic events. Labeling advises avoiding potent P-gp inducers.
How serious is the interaction between Carbamazepine and Edoxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another anticoagulant or antiepileptic. If unavoidable, monitor for thrombosis.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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