Drug interactions
Carbamazepine + Eplerenone
Severity: Moderate
Carbamazepine and Eplerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a CYP3A4 inducer and eplerenone is a CYP3A4 substrate, so eplerenone exposure may fall. This could reduce its antihypertensive or cardioprotective effect.
What this interaction means in plain words
Carbamazepine and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Eplerenone belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 increasing eplerenone metabolism.
What to do
Monitor blood pressure and clinical response, and increase the eplerenone dose if needed. Consider an alternative anticonvulsant if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Eplerenone?
MediHelp rates the interaction as moderate. Carbamazepine and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine is a CYP3A4 inducer and eplerenone is a CYP3A4 substrate, so eplerenone exposure may fall. This could reduce its antihypertensive or cardioprotective effect.
How serious is the interaction between Carbamazepine and Eplerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response, and increase the eplerenone dose if needed. Consider an alternative anticonvulsant if feasible.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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