Drug interactions
Carbamazepine + Macimorelin
Severity: Major
Carbamazepine and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may lower macimorelin exposure, which can produce false results on the growth hormone stimulation test used to diagnose growth hormone deficiency.
What this interaction means in plain words
Carbamazepine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
Carbamazepine induces CYP3A4, reducing macimorelin concentrations and its stimulation of growth hormone release.
What to do
Do not perform the test while the inducer is on board; discontinue carbamazepine with an adequate washout beforehand if clinically safe, or defer testing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Carbamazepine with Macimorelin?
MediHelp rates the interaction as major. Carbamazepine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine may lower macimorelin exposure, which can produce false results on the growth hormone stimulation test used to diagnose growth hormone deficiency.
How serious is the interaction between Carbamazepine and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not perform the test while the inducer is on board; discontinue carbamazepine with an adequate washout beforehand if clinically safe, or defer testing.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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