Drug interactions
Carbamazepine + Omeprazole
Severity: Moderate
Carbamazepine and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces omeprazole metabolism and may lower its levels, reducing acid suppression. Omeprazole may also modestly raise carbamazepine levels.
What this interaction means in plain words
Carbamazepine and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Carbamazepine induces CYP2C19 and CYP3A4, increasing omeprazole clearance; omeprazole may inhibit carbamazepine metabolism.
What to do
Monitor for reduced PPI effect and increase the dose if needed; check carbamazepine levels and watch for toxicity when starting omeprazole.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Omeprazole?
MediHelp rates the interaction as moderate. Carbamazepine and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces omeprazole metabolism and may lower its levels, reducing acid suppression. Omeprazole may also modestly raise carbamazepine levels.
How serious is the interaction between Carbamazepine and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced PPI effect and increase the dose if needed; check carbamazepine levels and watch for toxicity when starting omeprazole.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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